His Majesty has filmed a personal message concerning his battle with cancer, which will be broadcast as part of this year's fundraising drive, organised by medical research organisations and a television broadcaster.
The royal household confirmed the King would discuss his "path to recovery" as a cancer patient, in a video message on Friday evening at the evening slot.
The address, filmed within a royal residence a fortnight ago, will emphasise the vital significance of routine screenings to ensure more people catch the illness at an early stage.
This represents a rare update on the medical condition of the Monarch, who has been receiving ongoing care since revealing his diagnosis in early last year. However, it is believed doubtful the King will disclose his specific form of cancer.
The Stand Up To Cancer campaign each year collects money for medical research and treatment and encourages people to get health assessments to increase the odds of an early diagnosis.
The King's public discussion about his condition, and managing the disease, has been intended to raise awareness and to get more people to get checked - and this will be taken a step further with this unusual royal involvement.
To date the King's primary strategy to his cancer has been to continue his schedule, preserving a busy schedule alongside his frequent sessions of treatment, and he is understood not to have sought to be characterised by his diagnosis.
Recently has seen the King, 77, embarking on several overseas trips, notably to Italy and Canada, and hosting the highest tally of foreign dignitaries to the UK for a generation, including the German president recently.
Friday evening's Stand Up to Cancer show on television, hosted by well-known figures such as several TV personalities, will encourage people not to be scared of getting health screenings.
All three have been personally touched by cancer - one host revealed in November she had had an operation for the disease, while Clare Balding was overcame a thyroid condition in the past. Comedian Hills has previously spoken about his parent, who had stomach cancer and then later another illness.
The programme will reach out to the approximate nine million people in the UK who health organisations estimate are not compliant with NHS screening schemes, with an website to let people check if they are qualified for screenings for breast, bowel and cervical cancer.
In an bid to clarify cancer checks and illustrate the importance of prompt detection there will be a direct feed from cancer clinics at two Cambridge hospitals in Cambridge.
"The goal is to take the fear out of preventative tests and demonstrate the public that they are not isolated in this," stated a presenter.
At present in the UK, there are three NHS cancer screening programmes - for major health concerns - offered to certain age groups.
A emerging scheme for lung health is also being gradually implemented for anyone at increased risk of contracting the illness, specifically targeting people of a certain age, who are smokers or were former smokers.
Individuals may discuss prostate screenings, but there is no national programme operational.
The charity project, which has generated over one hundred million pounds since 2012, is financing 73 medical projects with many patients.
King Charles, in a message for guests at a reception for related organisations in earlier this year, had spoken of understanding the "daunting and at times alarming situation" for those diagnosed and their families.
But he stated his first-hand encounter of coping with cancer had shown him that "the most difficult times of illness can be brightened by the greatest compassion," as he thanked those who supported individuals with the illness.
Royal representatives has not made public the nature of cancer the King has, or what treatment he has undergone. The King's cancer was identified after he had received a medical treatment.
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